Carpe Vitae

Who we are

Driven by a core team of world-leading scientists, we are using our profound expertise in DNA damage repair and ageing research to develop ground-breaking products and solutions to help people live healthier, for longer.

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Your health

Transforming the future of health care, our research will bridge the gap between lifespan and healthspan.

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What we are doing

We are striving to treat, prevent and cure age-related diseases to revolutionise the meaning of ‘long-term health’.

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Research & technology

Our advanced technology and therapies are breaking new ground in age-related research globally.

Publications

6 April 2021 | Nucleic Acids Research

Barrier-to-autointegration-factor (Banf1) modulates DNA double-strand break repair pathway choice via regulation of DNA-dependent kinase (DNA-PK) activity

DNA repair pathways are essential to maintain the integrity of the genome and prevent cell death and tumourigenesis.

29 October 2020 | Scientific Reports

SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer

SASH1 (SAM and SH3 domain-containing protein 1) is a tumor suppressor protein that has roles in key cellular processes including apoptosis and cellular proliferation.

9 September 2020 | Frontiers in Cell and Developmental Biology

PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance

The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular processes, including the regulation of transcription, apoptosis and the DNA damage response.

12 May 2020 | GenScript Webinar

Identification and Characterization of a Novel Biomarker for Cancer Therapy

Genomic instability is a universal hallmark of all cancers. Many of the most commonly used chemotherapeutic agents target this genomic instability by directly damaging the DNA, which results in tumour cell death.

3 December 2019 | Nature Communications

Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage

The DNA repair capacity of human cells declines with age, in a process that is not clearly understood. Mutation of the nuclear envelope protein barrier-to-autointegration factor 1 (Banf1) has previously been shown to cause a human progeroid disorder, Néstor–Guillermo progeria syndrome (NGPS).

1 October 2019 | Journal of Thoracic Oncology

Banf1 Predicts Lung Cancer Survival and Sensitivity to Platinum-Based Chemotherapy

Barrier to autointegration factor 1 (BAF/Banf1) is a small, 10 kDa protein that functions as a non-specific DNA-binding homodimer and localises to the nuclear envelope during mitosis where it tethers DNA loops to the nuclear envelope.

10 November 2016 | Cell Death & Disease

Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response

Apoptosis is a highly regulated cellular process that functions to remove undesired cells from multicellular organisms. This pathway is often disrupted in cancer, providing tumours with a mechanism to avoid cell death and promote growth and survival.

14 September 2016 | Oncotarget

SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer

Expression of the SASH1 protein is reduced in a range of human cancers and has been implicated in apoptotic cancer cell death. This study investigated whether increasing SASH1 expression could be a useful therapeutic strategy in breast cancer.

12 December 2014 | BMC Molecular Biology

Néstor-Guillermo Progeria Syndrome: A biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation.

Premature aging syndromes recapitulate many aspects of natural aging and provide an insight into this phenomenon at a molecular and cellular level. The progeria syndromes appear to cause rapid aging through disruption of normal nuclear structure.