We’re changing what it means to live longer —
because we only get one life.
Who we are
Driven by a core team of world-leading scientists, we are using our profound expertise in DNA damage repair and ageing research to develop ground-breaking products and solutions to help people live healthier, for longer.
Your health
Transforming the future of health care, our research will bridge the gap between lifespan and healthspan.
What we are doing
We are striving to treat, prevent and cure age-related diseases to revolutionise the meaning of ‘long-term health’.
Research & technology
Our advanced technology and therapies are breaking new ground in age-related research globally.
Publications
6 April 2021 | Nucleic Acids Research
Barrier-to-autointegration-factor (Banf1) modulates DNA double-strand break repair pathway choice via regulation of DNA-dependent kinase (DNA-PK) activity
DNA repair pathways are essential to maintain the integrity of the genome and prevent cell death and tumourigenesis.
29 October 2020 | Scientific Reports
SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer
SASH1 (SAM and SH3 domain-containing protein 1) is a tumor suppressor protein that has roles in key cellular processes including apoptosis and cellular proliferation.
9 September 2020 | Frontiers in Cell and Developmental Biology
PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance
The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular processes, including the regulation of transcription, apoptosis and the DNA damage response.
12 May 2020 | GenScript Webinar
Identification and Characterization of a Novel Biomarker for Cancer Therapy
Genomic instability is a universal hallmark of all cancers. Many of the most commonly used chemotherapeutic agents target this genomic instability by directly damaging the DNA, which results in tumour cell death.
3 December 2019 | Nature Communications
Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage
The DNA repair capacity of human cells declines with age, in a process that is not clearly understood. Mutation of the nuclear envelope protein barrier-to-autointegration factor 1 (Banf1) has previously been shown to cause a human progeroid disorder, Néstor–Guillermo progeria syndrome (NGPS).
1 October 2019 | Journal of Thoracic Oncology
Banf1 Predicts Lung Cancer Survival and Sensitivity to Platinum-Based Chemotherapy
Barrier to autointegration factor 1 (BAF/Banf1) is a small, 10 kDa protein that functions as a non-specific DNA-binding homodimer and localises to the nuclear envelope during mitosis where it tethers DNA loops to the nuclear envelope.
10 November 2016 | Cell Death & Disease
Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response
Apoptosis is a highly regulated cellular process that functions to remove undesired cells from multicellular organisms. This pathway is often disrupted in cancer, providing tumours with a mechanism to avoid cell death and promote growth and survival.
14 September 2016 | Oncotarget
SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer
Expression of the SASH1 protein is reduced in a range of human cancers and has been implicated in apoptotic cancer cell death. This study investigated whether increasing SASH1 expression could be a useful therapeutic strategy in breast cancer.
12 December 2014 | BMC Molecular Biology
Néstor-Guillermo Progeria Syndrome: A biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation.
Premature aging syndromes recapitulate many aspects of natural aging and provide an insight into this phenomenon at a molecular and cellular level. The progeria syndromes appear to cause rapid aging through disruption of normal nuclear structure.