Transforming the future of health care, our research will bridge the gap between lifespan and healthspan.
We are striving to treat, prevent and cure age-related diseases to revolutionise the meaning of ‘long-term health’.
Our advanced technology and therapies are breaking new ground in age-related research globally.
6 April 2021 | Nucleic Acids Research
DNA repair pathways are essential to maintain the integrity of the genome and prevent cell death and tumourigenesis.
29 October 2020 | Scientific Reports
SASH1 (SAM and SH3 domain-containing protein 1) is a tumor suppressor protein that has roles in key cellular processes including apoptosis and cellular proliferation.
9 September 2020 | Frontiers in Cell and Developmental Biology
The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular processes, including the regulation of transcription, apoptosis and the DNA damage response.
12 May 2020 | GenScript Webinar
Genomic instability is a universal hallmark of all cancers. Many of the most commonly used chemotherapeutic agents target this genomic instability by directly damaging the DNA, which results in tumour cell death.
3 December 2019 | Nature Communications
The DNA repair capacity of human cells declines with age, in a process that is not clearly understood. Mutation of the nuclear envelope protein barrier-to-autointegration factor 1 (Banf1) has previously been shown to cause a human progeroid disorder, Néstor–Guillermo progeria syndrome (NGPS).
1 October 2019 | Journal of Thoracic Oncology
Barrier to autointegration factor 1 (BAF/Banf1) is a small, 10 kDa protein that functions as a non-specific DNA-binding homodimer and localises to the nuclear envelope during mitosis where it tethers DNA loops to the nuclear envelope.
10 November 2016 | Cell Death & Disease
Apoptosis is a highly regulated cellular process that functions to remove undesired cells from multicellular organisms. This pathway is often disrupted in cancer, providing tumours with a mechanism to avoid cell death and promote growth and survival.
14 September 2016 | Oncotarget
Expression of the SASH1 protein is reduced in a range of human cancers and has been implicated in apoptotic cancer cell death. This study investigated whether increasing SASH1 expression could be a useful therapeutic strategy in breast cancer.
12 December 2014 | BMC Molecular Biology
Premature aging syndromes recapitulate many aspects of natural aging and provide an insight into this phenomenon at a molecular and cellular level. The progeria syndromes appear to cause rapid aging through disruption of normal nuclear structure.